Why the study?
Does extending the intravenous bolus injection time of disopyramide from 5 minutes to 20 minutes reduce the decrease in cardiac output in patients with ischaemic heart disease?
Population
n=7 patients with ischaemic heart disease
Comparison
Disopyramide 150 mg intravenous bolus given over… vs Disopyramide 150 mg intravenous bolus given over…
Design
RCT, randomised cross-over, open
Authors
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Extending disopyramide bolus to 20 min does not lessen cardiac index drop; supports retaining standard 5-min administration in ischaemic heart disease.
Does extending the intravenous bolus injection time of disopyramide from 5 minutes to 20 minutes reduce the decrease in cardiac output in patients with ischaemic heart disease?
Extending the intravenous bolus injection time of disopyramide from 5 to 20 minutes does not prevent the associated decrease in cardiac output, supporting the continued use of the standard 5-minute administration.
Bonde et al. (1987) studied this question.
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