Key result
Intravenous disopyramide significantly shortened sinus cycle length and prolonged atrial and ventricular effective refractory periods, with maximal effects at 5 minutes.
Why the study?
What are the electrophysiological effects of intravenous disopyramide in fasting, unpremedicated patients?
Population
17 patients, fasting, unpremedicated, and off all medication for three days. Includes 6 patients with bundle…
Design
Case_series
Follow-up
30 minutes
Authors
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May inform procedural timing of EP effects after IV disopyramide; leaves open safety in conduction disease.
What are the electrophysiological effects of intravenous disopyramide in fasting, unpremedicated patients?
Intravenous disopyramide prolongs atrial and ventricular effective refractory periods but can worsen intraventricular conduction in patients with pre-existing His-Purkinje disease.
Ross et al. (1978) studied this question. Intravenous disopyramide phosphate was evaluated on Electrophysiological effects including sinus cycle length and refractory periods. Intravenous disopyramide significantly shortened sinus cycle length and prolonged atrial and ventricular effective refractory periods, with maximal effects at 5 minutes.
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