Key result
IV disopyramide shows no overall sinus node effect but markedly depresses function in severe bradycardia.
Why the study?
The electrophysiologic effects of intravenously administered disopyramide on sinus node function in patients with sinus node dysfunction were not well characterized.
Does intravenous disopyramide affect sinus node function in patients with sinus node dysfunction?
Population
16 symptomatic patients with sinus node dysfunction subdivided into group A (n=8) and group B (n=8)
Comparison
Intravenous disopyramide (2 mg/kg) vs baseline control conditions
Design
Case series
Authors
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May warrant caution with disopyramide in severe sinus node dysfunction; hypothesis-generating for targeted sinus node assessment.
Does intravenous disopyramide affect sinus node function in patients with sinus node dysfunction?
Disopyramide should be administered cautiously in patients with sinus node dysfunction, as it can cause marked depression of sinus node function and SA exit block in a susceptible subset.
LaBarre et al. (1979) studied Sinus node dysfunction (n=16). Disopyramide phosphate vs. Baseline (before study) was evaluated on Spontaneous cycle length, maximum sinus node recovery time, and estimated SA conduction time. Intravenous disopyramide produced no significant overall difference in sinus node function parameters, but caused marked depression in patients with severe sinus bradycardia or sinus pauses.
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