Why the study?
Does intravenous disopyramide alter electrophysiological parameters or cause advanced block in patients with bundle branch block?
Population
22 patients with intraventricular conduction delay (bundle branch block)
Comparison
Intravenous infusion of disopyramide, 2 mg/kg vs Baseline (before intravenous infusion)
Design
Cohort
Follow-up
30 minutes
Authors
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May support short-term safety in bundle branch block despite conduction delay; leaves open need for randomized confirmation.
Does intravenous disopyramide alter electrophysiological parameters or cause advanced block in patients with bundle branch block?
Intravenous disopyramide significantly prolongs infranodal conduction time and refractoriness but appears safe in patients with bundle branch block without causing advanced atrioventricular block.
Desai et al. (1979) studied this question.
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