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June 1, 1981Circulation ResearchOpen Access

Electrophysiological effects of the optical isomers of disopyramide and quinidine in the dog. Dependence on stereochemistry.

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Why the study?

Do the optical isomers of disopyramide and quinidine have different electrophysiological effects on canine cardiac Purkinje fibers?

Population

Canine cardiac Purkinje fibers

Design

Preclinical

Follow-up

60 minutes

Authors

MMMichael MirroParkview HealthAWAugust M. WatanabeEli Lilly (United States)JBJ C BaileyUniversity of Indianapolis

Discussion

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Implication

Animal Purkinje data on isomer-specific APD effects should not change practice; leaves open stereoselective mechanisms in human arrhythmias.

Structured PICO

Do the optical isomers of disopyramide and quinidine have different electrophysiological effects on canine cardiac Purkinje fibers?

P
Population
Canine cardiac Purkinje fibers
I
Intervention
Racemic disopyramide, (+)-disopyramide, (-)-disopyramide, quinidine, and quinine
O
Outcome
Action potential duration (APD) measured at 90% repolarization, dV/dt of phase 0, conduction time, and current requirement for all-or-none depolarizationsurrogate

The stereochemical configurations of disopyramide and quinidine determine their specific directionally opposite effects on the repolarization of cardiac Purkinje fibers.

Cite This Study

Mirro et al. (1981) studied this question.

synapsesocial.com/papers/6a82fb07b15ea8a8ea4ccb24https://doi.org/10.1161/01.res.48.6.867
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electrophysiological effects of disopyramide and quinidine on guinea pig atria and canine cardiac purkinje fibers. Dependence on underlying cholinergic tone.1980 · 42 citations
  2. 2Electrophysiological actions of disopyramide phosphate on canine ventricular muscle and purkinje fibers.1975 · 65 citations
  3. 3Effect of lidocaine and quinidine on steady-state characteristics and recovery kinetics of (dV/dt)max in guinea pig ventricular myocardium.1975 · 203 citations
  4. 4Sites of action and active forms of lidocaine and some derivatives on cardiac Purkinje fibers.1978 · 28 citations
  5. 5Blood Quinidine Concentrations as a Guide in the Treatment of Cardiac Arrhythmias1950 · 109 citations