Key result
Angiographic assessment of tumor vascularity identified 40% of histologic responders and 91% of nonresponders after two courses of chemotherapy, and 91% and 50% respectively after a median of four.
Why the study?
Does angiographic assessment of tumor vascularity accurately identify histologic response to preoperative chemotherapy in patients with high-grade osteosarcoma?
Population
81 patients with high-grade osteosarcoma
Comparison
Angiographic assessment of tumor vascularity… vs Histologic tumor necrosis of resected specimens
Design
Cohort
Authors
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May support response-adapted chemotherapy in osteosarcoma; leaves open prospective validation against histologic and survival endpoints.
Observational (n=81)
Does angiographic assessment of tumor vascularity accurately identify histologic response to preoperative chemotherapy in patients with high-grade osteosarcoma?
Angiographic assessment of tumor vascularity provides a useful guideline for determining preoperative chemotherapy strategy in osteosarcoma.
Carrasco et al. (1989) conducted an observational in Osteosarcoma (n=81). Angiographic assessment of tumor vascularity vs. Histologic tumor necrosis was evaluated on Identification of histologic responders and nonresponders. Angiographic assessment of tumor vascularity identified 40% of histologic responders and 91% of nonresponders after two courses of chemotherapy, and 91% and 50% respectively after a median of four.
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