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Solid form screen of anti-hyperammonemic drug carglumic acid (CGA) resulted in two polymorphs, Form-I and Form-II. The crystal structure of Form-I is sustained by an acid catemer synthon, whereas Form-II has an acid–amide heterosynthon. Slurry grinding, thermal stress, stability measurements, and DVS analysis confirm the thermodynamic stability of Form-I.
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Maddileti et al. (2015) studied this question.
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