Key result
A subgroup of patients with autism produced elevated antibodies against Purkinje cells and gliadin peptides simultaneously, indicating potential cross-reactivity.
Case-Control (n=100)
A subgroup of patients with autism produce cross-reactive antibodies against Purkinje cells and gliadin peptides, suggesting a potential autoimmune mechanism for some neurological symptoms.
No takes yet. Share an insight, caveat, or question.
Does not support dietary interventions in autism; leaves open whether gliadin-Purkinje cross-reactivity contributes to symptoms in a subgroup.
Vojdani et al. (2004) conducted a case-control in Autism (n=100). Autism vs. Healthy controls was evaluated on Reactivity of sera to specific peptides from gliadin and the cerebellum. A subgroup of patients with autism produced elevated antibodies against Purkinje cells and gliadin peptides simultaneously, indicating potential cross-reactivity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: