Key result
Influenza vaccine linked to ~95% lower HF hospitalization in ACS patients on beta-blockers.
Why the study?
Influenza vaccination reduces adverse outcomes in ACS, but the interaction between influenza vaccine and other treatments on cardiovascular prognosis is unknown.
Does inactivated influenza vaccine reduce major cardiovascular events in patients with acute coronary syndrome?
Population
439 ACS patients from Phrommintikul et al
Comparison
Influenza vaccination vs no vaccination
Design
Observational cohort study with stratified and multivariable Cox regression analysis
Authors
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Hypothesis-generating for HF hospitalization reduction with influenza vaccine in beta-blocker-treated ACS; prospective trials needed before practice change.
Observational (n=439)
Does inactivated influenza vaccine reduce major cardiovascular events in patients with acute coronary syndrome?
Hazard Ratio: 0.05 (95% CI 0.004–0.71)
p-value: p=0.027
Influenza vaccination significantly modifies the effect of beta-blockers in ACS patients, leading to a marked reduction in heart failure hospitalizations.
Sribhutorn et al. (2016) conducted an observational in Acute coronary syndrome (ACS) (n=439). Inactivated influenza vaccine was evaluated on Hospitalization due to heart failure in patients receiving beta-blockers (HR 0.05, 95% CI 0.004-0.71, p=0.027). Inactivated influenza vaccine significantly reduced hospitalization due to heart failure in acute coronary syndrome patients receiving beta-blockers (HR 0.05; 95% CI 0.004-0.71; P=0.027).
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