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Cryptococcosis is a rare infection that can affect the central nervous system (CNS), leading to neurological complications. Neurocryptococcoma, though uncommon, can present with significant morbidity. We report the case of a 31-year-old immunocompetent woman who developed a large posterior fossa neurocryptococcoma. The lesion was successfully treated with complete surgical resection via occipital craniotomy. Diagnosing a cryptococcal infection can be challenging due to its rarity and the variability of its presentation. Management typically involves either medical or surgical interventions based on lesion characteristics. This case highlights the importance of considering neurocryptococcoma in the differential diagnosis for patients with neurological symptoms, even in those without apparent immune deficiency.
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Spenazato et al. (2025) studied this question.
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