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An unlikely hero: Selective small-molecule recognition of a specific DNA secondary structure, instead of hybridization, can be exploited to template catalysis between two reactants. Here, we show that a proline-tethered quadruplex DNA, as shown in the figure, can serve as catalyst for the aldol reaction between a porphyrin-bearing aldehyde and a ketone.
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Tang et al. (2008) studied this question.
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