Key result
Nifedipine, captopril, and prazosin control severe hypertension in pediatric Guillain-Barré syndrome without beta-blockers.
Why the study?
Hypertension is frequently observed in Guillain-Barré syndrome patients with various underlying mechanisms implicated, including sympathetic overactivity and renin-catecholamine increases.
Case Report (n=1)
Hypertension secondary to sympathetic overactivity in a child with Guillain-Barré syndrome can be effectively managed with nifedipine, captopril, and prazosin without beta-blockade.
Answers are grounded in this paper and cite their sources.
May inform BP management in pediatric GBS encephalopathy; leaves open mechanistic confirmation in larger cohorts.
Hypertension has often been observed in patients with Guillain-Barré syndrome, and various underlying mechanisms have been implicated. We report the case of a child with the Guillain-Barré syndrome whose hypertension was associated with increases in both renin activity and circulating catecholamines. This case also appeared to be complicated by hypertensive encephalopathy. Following administration of intravenous regitine, a blood pressure change was observed and cardiac performance was assessed by two-dimensional echocardiography. Results indicated that increased total peripheral resistance may have been responsible for the symptoms and the hypertension. The hypertension was effectively managed by nifedipine, captopril and prazosin without the need for beta-blockade.
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Okada et al. (1996) conducted a case report in Guillain-Barré syndrome with hypertension and hypertensive encephalopathy (n=1). Nifedipine, captopril, and prazosin was evaluated. Hypertension in a child with Guillain-Barré syndrome and hypertensive encephalopathy was effectively managed by nifedipine, captopril, and prazosin without the need for beta-blockade.
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