Calcium alginate microparticles containing anti-TB drugs

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In this work the results of immobilization of anti-TB drugs rifampicin and fluconazole in alginate hydrogels were presented. Release kinetics of rifampicin and fluconazole fromswollen and dried calcium alginate microparticles were studied. It was revealed that the release of the drug from the swollen microparticles is higher than from the dried ones. Also the release of rifampicin from alginate microparticles coated with chitosan layer was studied. It was investigated that the thicker the layer of chitosan is, the slower drug releases. Thus, for the chitosan coating thickness of 25 microns, 95-100% rifampicin diffuses from the microparticles for 600-720 min. When using alginate-coated particles with a thickness of 65 microns and 125, during this time interval 60-70% drug released, respectively.