Key result
Intranasal midazolam at 0.3 mg/kg resulted in a significantly higher rate of adequate sedation at 5 minutes compared to 0.2 mg/kg (80% vs 40%) in children undergoing elective surgery.
Why the study?
Does intranasal midazolam 0.3 mg/kg improve sedation onset and conditions for parental separation compared to 0.2 mg/kg in pediatric patients undergoing elective surgery?
RCT (n=60)
Does intranasal midazolam 0.3 mg/kg improve sedation onset and conditions for parental separation compared to 0.2 mg/kg in pediatric patients undergoing elective surgery?
Absolute Event Rate: 80% vs 40%
Intranasal midazolam 0.3 mg/kg provides earlier onset of sedation and better conditions for parental separation compared to 0.2 mg/kg in pediatric patients undergoing surgery.
May support 0.3 mg/kg intranasal midazolam for pediatric premedication; extends RCT dosing comparisons for sedation onset.
Introduction: Intranasal midazolam is convenient form of premedication in children with favourable pharmacokinetics and no side-effects. This study was carried out to compare two different doses of intranasal midazolam as premedication in paediatric surgery. Materials and Methods: After taking institutional ethics committee approval and informed consent, sixty patients aged 2 to 6 years undergoing elective surgeries were randomised into two groups (n=30 each) to receive 0.2mgkg1 (Group A) and 0.3 mgkg1 (Group B) intranasal midazolam in the pre-operative area. Vital parameters were taken at 5 minute intervals till sevoflurane induction. 5-point sedation score was recorded at 5 minutes, 10 minutes, after parental separation at 15 minutes and modified to show compliance with fack mask induction at 20 minutes. Side effects during the study were also compiled. Results: Demographic data including age, gender and weight distribution were comparable in both groups. All haemodynamic parameters remained similar in both the groups (P>0.05). Significantly higher number of patients (24 versus 12 in group B and A respectively) had onset of sedation (score 3, 4) at 5 minutes while sedation levels were comparable at 10 minutes. Lesser number became agitated on parental separation and face mask induction (P-values 0.044, 0.126 respectively) in group B, former being significant. No side effects were observed during the study. Conclusion: Intranasal midazolam in both the dosages provides satisfactory conditions for parental separation and face mask induction in children. However, larger dose can be used for earlier onset, with higher probability of adequate sedation levels, no side effects deterring its use.
No takes yet. Share an insight, caveat, or question.
Singh et al. (2020) conducted an RCT in Paediatric surgery (n=60). Intranasal midazolam vs. 0.2 mg/kg intranasal midazolam was evaluated on Onset of sedation (score 3, 4) at 5 minutes. Intranasal midazolam at 0.3 mg/kg resulted in a significantly higher rate of adequate sedation at 5 minutes compared to 0.2 mg/kg (80% vs 40%) in children undergoing elective surgery.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: