Key result
Chronic electroconvulsive shock induced a significant decrease in noradrenaline- and forskolin-stimulated cyclic AMP production in rat cortical slices compared to a single shock.
Why the study?
Does chronic electroconvulsive shock alter cyclic AMP production and adenylate cyclase activity in rat cortical preparations compared to a single shock?
Does chronic electroconvulsive shock alter cyclic AMP production and adenylate cyclase activity in rat cortical preparations compared to a single shock?
Chronic electroconvulsive shock alters cyclic AMP signal transduction at components of the adenylate cyclase enzyme distal to the receptor in rat models.
Chronic ECS effects on cortical cAMP vary by preparation; leaves open translation to ECT mechanisms in humans.
Chronic electroconvulsive shock (ECS) induced a significant decrease in noradrenaline- and forskolin-stimulated cyclic AMP production in rat cortical slices, whereas a single ECS had a much smaller effect. In a cortical membrane preparation, adenylate cyclase activity in response to stimulation by forskolin, guanosine-5'-(beta,gamma-imido) triphosphate, and Mn2+ ions was significantly increased in membranes derived from rats that had received chronic ECS, but was either unchanged or reduced in membranes from rats that received a single treatment only. The results are interpreted in terms of changes occurring at components of the adenylate cyclase enzyme distal to the receptor.
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Newman et al. (1986) studied this question. Chronic electroconvulsive shock (ECS) vs. Single ECS was evaluated on Cyclic AMP production and adenylate cyclase activity. Chronic electroconvulsive shock induced a significant decrease in noradrenaline- and forskolin-stimulated cyclic AMP production in rat cortical slices compared to a single shock.
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