Key result
Multimodality imaging, particularly LV GLS, effectively tracks treatment response and prognostication in cardiac amyloidosis.
Why the study?
Technological advances in multimodality cardiac imaging have improved diagnosis and prognosis of cardiac amyloidosis, but optimal timing for imaging to assess treatment response remains to be clarified.
Does multimodality cardiac imaging help assess treatment response in patients with cardiac amyloidosis?
Does multimodality cardiac imaging help assess treatment response in patients with cardiac amyloidosis?
Multimodality imaging, particularly left ventricular global longitudinal strain, is crucial for tracking treatment response and prognosticating disease burden in cardiac amyloidosis.
Answers are grounded in this paper and cite their sources.
LV GLS may refine prognosis in cardiac amyloidosis; leaves open whether serial changes alter management.
PURPOSE OF REVIEW: Cardiac amyloidosis is characterized by systolic and diastolic abnormalities due to deposition of amyloid fibril within the myocardial extracellular space. Technological advances in multimodality cardiac imaging now helps in accurate diagnosis and prognosis of this disease. With technological advances in imaging, it is now easier to follow up these patients whether they are getting response to therapy. RECENT FINDINGS: Left ventricular global longitudinal strain assessment is an important noninvasive tool to track response to treatment in cardiac amyloidosis patient. SUMMARY: Present era has shown the importance of using multimodality imaging to understand the pathophysiology of this disease which has been supplemented by both imaging and blood biomarkers. These help in prognosticating the disease burden and to assess treatment response. Future research is now focused on the use of artificial intelligence and precision medicine to detect of changes earlier in the course of treatment.
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Shantanu P. Sengupta (2025) conducted a review in Cardiac amyloidosis. Multimodality cardiac imaging was evaluated. Multimodality cardiac imaging, particularly left ventricular global longitudinal strain, is an important noninvasive tool to track treatment response and prognosticate disease in cardiac amyloidosis.
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