The structure of the potent nematicide omphalotin, isolated from the mycelia of the basidiomycete Omphalotus olearius, was determined by spectroscopic techniques. Omphalotin is a cyclic dodecapeptide consisting of 3 glycine, 5 valine, 3 isoleucine and 1 tryptophane, and 9 of the 12 β-nitrogens are methylated. HMBC and NOESY correlations between the N-methyl groups and the β-carbons/β-hydrogens established the sequence of amino acids.
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Sterner et al. (1997) studied this question.