Key result
Male sex is linked to ~2-fold higher odds of confirmed CAD after positive treadmill testing.
Why the study?
The diagnostic accuracy of treadmill test to rule out coronary artery disease is uncertain due to limitations in interpretation and the invasive nature of coronary angiography.
What is the predictive value of a positive treadmill test for angiographically confirmed coronary artery disease?
Cross-Sectional (n=303)
No
What is the predictive value of a positive treadmill test for angiographically confirmed coronary artery disease?
Odds Ratio: 2.08 (95% CI 1.3–3.32)
Absolute Event Rate: 53% vs 35%
p-value: p=0.002
A positive treadmill test is most predictive of true coronary artery disease in males and patients with multiple cardiovascular risk factors, highlighting a high rate of false positives in lower-risk individuals.
TMT-positive results warrant risk-stratified interpretation before angiography; leaves open refined pretest probability assessment in CAD diagnosis.
Background and Aims: The use of coronary angiography in diagnosing coronary artery disease is limited by its invasive property. In the other hand correct interpretation of tread mill test data and its use as a key diagnostic modality also has been a problem. The study was thus aimed to see the diagnostic accuracy of treadmill test to rule out coronary artery disease.Methods: We included all the patients who had positive tread mill stress test and underwent coronary angiography and were subsequently analyzed for presence of coronary artery disease.Results: A total of 303 patients were included with 119 males and 184 females with mean age of 53.6±10.5 yrs and 51.7±8.6 yrs respectively. Normal coronaries was seen in 114(54.0%), borderline lesion in 29 (13.7%) and significant lesion in 68 (32.2%) with 48(22.7%) having single vessel disease, 29(13.7%) double vessel disease and 14(6.6%) triple vessel disease. Coronary artery diseases was highest among diabetics (57.7%, OR 1.72 (95 % CI: 0.92 to 3.20), p value-0.08).Similarly the risk of coronary artery disease was significantly highest among patient with ≥2 risk factor (OR: 8.10,95 % CI: 4.96 to 13.24, P < 0.0001). Gender distribution showed that coronary artery disease was significantly higher in males than females (53% vs 35% respectively, OR: 2.08, 95 % CI: 1.30 to 3.32, p value-0.002).Conclusion: The value of tread mill test to predict coronary artery disease is highest in patients with two or more risk factor especially in those with diabetes with significance increased among males.
No takes yet. Share an insight, caveat, or question.
Shrestha et al. (2017) conducted a cross-sectional in Suspected coronary artery disease (n=303). Male gender vs. Female gender was evaluated on Presence of coronary artery disease on angiography (OR 2.08, 95% CI 1.30 to 3.32, p=0.002). In patients with a positive exercise treadmill test, male gender was associated with a significantly higher rate of confirmed coronary artery disease compared to females (53% vs 35%, OR 2.08).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: