Key result
Male sex linked to ~2-fold higher likelihood of confirmed CAD after positive stress test.
Why the study?
Treadmill test is widely used to screen for CAD but its interpretation requires confirmation by coronary angiography to guide diagnosis and treatment strategies.
Population
303 patients with positive treadmill stress test using Bruce protocol at a tertiary care center
Comparison
Treadmill test positive patients undergoing selective coronary angiography
Design
Cross-sectional study
Authors
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Positive TMT poorly predicts significant CAD; leaves open optimized pretest probability use in observational cohorts.
Cross-Sectional (n=303)
No
Odds Ratio: 2.08 (95% CI 1.3–3.32)
Absolute Event Rate: 53% vs 35%
p-value: p=0.002
A positive treadmill stress test has a high false-positive rate (54% normal coronaries), highlighting the need for further non-invasive imaging or risk stratification, especially in females and those with fewer CAD risk factors.
Shrestha et al. (2017) conducted a cross-sectional in Suspected coronary artery disease (n=303). Male gender vs. Female gender was evaluated on Presence of coronary artery disease on angiography (OR 2.08, 95% CI 1.30-3.32, p=0.002). Among patients with a positive treadmill stress test, males had a significantly higher likelihood of having angiographically confirmed coronary artery disease compared to females (53% vs 35%, OR 2.08).
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