Key result
Serum soluble DPP-4 levels are linked to renal dysfunction, but not coronary calcium, in T2D.
Why the study?
The association between serum soluble DPP-4 levels and renal function or cardiovascular risk in patients with type 2 diabetes mellitus was unclear.
Does serum soluble DPP-4 level correlate with renal function or cardiovascular risk in patients with type 2 diabetes mellitus?
Observational (n=140)
Does serum soluble DPP-4 level correlate with renal function or cardiovascular risk in patients with type 2 diabetes mellitus?
Serum soluble DPP-4 levels are significantly associated with decreased renal function in patients with type 2 diabetes mellitus, suggesting its potential utility as a biomarker.
sDPP-4 levels associated with worse renal function but not CAC in T2DM; leaves open biomarker role pending prospective validation.
BACKGROUND: Dipeptidyl peptidase-4 (DPP-4) is strongly expressed in the kidney, and soluble levels of this protein are used as a marker in various chronic inflammatory diseases, including diabetes, coronary artery disease, and cancer. This study examined the association between the serum soluble DPP-4 levels and renal function or cardiovascular risk in patients with type 2 diabetes mellitus. METHODS: In this retrospective analysis, soluble DPP-4 levels were measured in preserved sera from 140 patients with type 2 diabetes mellitus who had participated in our previous coronary artery calcium (CAC) score study. The associations of soluble DPP-4 levels with serum creatinine and GFR remained significant after adjusting for age, body mass index, and duration of diabetes. However, no associations were observed between soluble DPP-4 levels and the body mass index, waist circumference, or CAC score. CONCLUSION: These data suggest the potential use of serum soluble DPP-4 levels as a future biomarker of deteriorated renal function in patients with type 2 diabetes mellitus.
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Cho et al. (2018) conducted an observational in Type 2 diabetes mellitus (n=140). Serum soluble DPP-4 levels was evaluated on Renal function (serum creatinine and GFR) and cardiovascular risk (CAC score) (p==0.001). Serum soluble DPP-4 levels were significantly associated with serum creatinine and GFR (P=0.001), but not with coronary artery calcium score, in patients with type 2 diabetes mellitus.
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