Key result
American women show higher renin and aldosterone vs Japanese women with higher sodium excretion and BP.
Why the study?
Circadian rhythms of the renin-angiotensin-aldosterone system and electrolytes in young healthy women from Japan and the USA were compared to understand physiological differences.
Do circadian rhythms of the renin-angiotensin-aldosterone system and electrolytes differ between healthy young women in Japan and the USA?
Observational
Yes
Do circadian rhythms of the renin-angiotensin-aldosterone system and electrolytes differ between healthy young women in Japan and the USA?
Higher dietary salt consumption in Japanese women compared to American women is associated with higher blood pressure and suppression of the renin-angiotensin-aldosterone system.
Answers are grounded in this paper and cite their sources.
RAA circadian rhythms similar across populations despite dietary salt differences; leaves open salt's causal role in absolute levels and BP.
Circadian rhythms of the renin-angiotensin-aldosterone (R-A-A) system and electrolytes were evaluated in young healthy Fukuokan (Japan) and Minnesotan (USA) women. A similar protocol was used and each group remained on its usual diet. Blood was taken for 24 h at 4 h intervals from 8 a.m. during which time urine samples were also collected. The determinations in both groups were made in a laboratory in Japan. Plasma renin activity, plasma aldosterone concentration and aldosterone excretion rate showed similar circadian rhythms in both groups. However, those values at each sampling time and each span were always significantly higher in the Americans while the urinary Na and Cl excretions and blood pressure were higher in Japanese. The significant differences in the R-A-A system and blood pressure levels between these two groups may be due to the large amount of salt consumed by the Japanese.
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Kawasaki et al. (1983) conducted an observational in Clinically healthy. Japanese cohort (Fukuoka) vs. American cohort (Minnesota) was evaluated on Circadian rhythms of the renin-angiotensin-aldosterone system and electrolytes. American women had significantly higher plasma renin and aldosterone levels, whereas Japanese women had higher urinary sodium and chloride excretions and blood pressure.
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