Key result
Age under 65 linked to ~10% higher pulmonary embolism incidence in metastatic lung cancer.
Why the study?
Venous thromboembolism is a common complication in lung cancer patients, but the role of age in VTE incidence among metastatic lung cancer patients was unclear.
Does age under 65 years increase the incidence of venous thromboembolism in patients with metastatic lung cancer?
Observational (n=182,863)
Yes
Does age under 65 years increase the incidence of venous thromboembolism in patients with metastatic lung cancer?
Effect estimate: 356.82 more cases per 100,000 individuals
Absolute Event Rate: 3782.21% vs 3425.38%
p-value: p=<0.0001
Younger patients (under 65 years) with metastatic lung cancer have a significantly higher incidence of VTE compared to older patients, highlighting a high-risk subgroup that may benefit from prophylactic anticoagulation.
May flag younger metastatic lung cancer patients for heightened VTE vigilance; leaves open whether age-tailored prophylaxis improves outcomes.
Venous thromboembolism (VTE) is a common complication in cancer patients and is associated with increased morbidity and mortality. Lung cancer is commonly associated with VTE including pulmonary embolism. We did a retrospective analysis from the 2013 Healthcare Cost and Utilization Project data to determine the role of age as a factor in the development of VTE in this patient group. Patients were selected using the International Classification of Diseases, Ninth Revision (ICD-9) diagnosis codes for metastatic lung cancer and VTE. The patients were stratified by age, sex, race/ethnicity, and site of VTE. There was a total of 16,577 VTE events detected out of a total of 182,863 cases of metastatic lung cancer, representing 9% of the total cases. In patients under 65 years of age, there were 356.82 more cases of pulmonary embolism per 100,000 individuals compared to those older than 65 years (p<0.0001). The same age group also showed 374.83 more upper extremity VTE, 286.94 more non-pulmonary thoracic VTE, and 263.97 more abdominal VTE events per 100,000 individuals (p<0.0001). In conclusion, we found that patients under the age of 65 years had a significantly higher incidence of VTE, pulmonary embolism, upper extremity VTE as well as abdominal and non-pulmonary VTE.
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Bagchi et al. (2021) conducted an observational in Metastatic lung cancer (n=182,863). Age less than 65 years vs. Age 65 years or older was evaluated on Incidence of pulmonary embolism (356.82 more cases per 100,000 individuals, p=<0.0001). Patients under 65 years of age with metastatic lung cancer had a significantly higher incidence of pulmonary embolism compared to those 65 years or older (356.82 more cases per 100,000 individuals).
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