Sickle Cell-Hemoglobin D Disease

Article1 January 1959SICKLE CELL-HEMOGLOBIN D DISEASEERNEST W. SMITH, C. LOCKARD CONLEY, F.A.C.P.ERNEST W. SMITHSearch for more papers by this author, C. LOCKARD CONLEY, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-1-94 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSoon after the discovery that sickle (S) hemoglobin can be differentiated from normal (A) hemoglobin by electrophoresis,1other abnormalities of hemoglobin were recognized. In studying a white patient who previously had been thought to have sickle cell anemia, Itano2found that the erythrocytes of the mother could not be made to sickle, although the electrophoretic pattern was indistinguishable from that of sickle cell trait. The abnormal hemoglobin which did not produce sickling also differed from S hemoglobin because of its normal solubility in the reduced state, and was subsequently designated ashemoglobin D. The atypical hemolytic disorder in the patient...Bibliography1. PaulingItanoSingerWells LHASJIC: Sickle cell anemia, a molecular disease, Science 110: 543, 1949. CrossrefMedlineGoogle Scholar2. Itano HA: A third abnormal hemoglobin associated with hereditary hemolytic anemia, Proc. Nat. Acad. Sc. 37: 775, 1951. CrossrefMedlineGoogle Scholar3. CabannesSendraDalaut RL: Hemoglobin D—a hereditary hemoglobin abnormality in an Algerian Mussulman—observations of two families, Algérie méd. 59: 387, 1955. MedlineGoogle Scholar4. AksoyLehmann MH: A further example of hemoglobin D in a Turkish family, Tr. Roy. Soc. Trop. Med. and Hyg. 50: 178, 1956. CrossrefMedlineGoogle Scholar5. BirdLehmann GWH: Letter to the editor: Hemoglobin D in India, Brit. M. J. 1: 514, 1956. CrossrefGoogle Scholar6. 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ShelleyCurtis WHEM: Bone marrow embolism in sickle cell anemia and sickle cell-hemoglobin C disease, Bull. Johns Hopkins Hosp. 103: 8, 1958. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication October 28, 1957.From the Department of Medicine, The Johns Hopkins University School of Medicine and Hospital.†Department of Medicine of the Howard Hughes Medical Institute.This investigation was supported in part by a Research Grant of the Division of Research Grants and Fellowships, National Institutes of Health.Requests for reprints should be addressed to Ernest W. Smith, M.D., Assistant Professor of Medicine, The Johns Hopkins Hospital, Baltimore 5, Maryland. 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PAGE, M.D.Hemoglobin S-D DiseaseM. J. CAWEIN, M.D., E. J. LAPPAT, M.D., R. W. BRANGLE, M.D., C. H. FARLEY, M.D.Sickle Cell Hemoglobin D Disease in a Negro Colombian PatientALBERTO M. RESTREPO, M.D., OSCAR G. LONDOÑO, M.D.Abnormal human haemoglobins VIII. chemical studies on haemoglobin DHämoglobin DHereditary persistence of fetal hemoglobinMedical genetics 1959Clinical and Physiologic Studies in a Negro with Sickle-Cell Hemoglobin D Disease 1 January 1959Volume 50, Issue 1Page: 94-105KeywordsAnemiaFellowshipsGeneticsHemoglobinHospital medicinePneumonitisResearch grantsStem cells Issue Published: 1 January 1959 PDF downloadLoading ...