Key result
Intrathecal morphine added to thoracic epidural cuts 24-hour post-esophagectomy pain scores ~62%.
Why the study?
The study aimed to determine whether adding lumbar intrathecal morphine to standard thoracic epidural anesthesia reduces postoperative pain scores, opioid consumption, and epidural drug requirement after abdomino-thoracic esophagectomy.
Does the addition of lumbar intrathecal morphine to standard thoracic epidural anesthesia improve postoperative pain scores and reduce epidural drug requirements in patients undergoing abdomino-thoracic esophagectomy?
Population
50 patients undergoing abdomino-thoracic esophagectomy
Comparison
Lumbar intrathecal morphine plus thoracic epidural anesthesia vs thoracic epidural anesthesia alone
Design
Randomized controlled trial
Authors
Loading...
Supports adding intrathecal morphine to thoracic epidural for esophagectomy; extends multimodal neuraxial evidence in major thoracic surgery.
RCT (n=50)
Randomized
No
Does the addition of lumbar intrathecal morphine to standard thoracic epidural anesthesia improve postoperative pain scores and reduce epidural drug requirements in patients undergoing abdomino-thoracic esophagectomy?
Absolute Event Rate: 0.92% vs 2.44%
p-value: p=0.0001
The addition of lumbar intrathecal morphine to standard thoracic epidural anesthesia significantly improves postoperative pain control and reduces epidural drug requirements in patients undergoing abdomino-thoracic esophagectomy.
Das et al. (2022) conducted an RCT in Carcinoma esophagus undergoing abdomino thoracic esophagectomy (n=50). Lumbar intrathecal morphine plus thoracic epidural anesthesia vs. Thoracic epidural anesthesia alone was evaluated on Pain score (Numerical Rating Scale) at 24 hours postoperatively (p=0.0001). Adding lumbar intrathecal morphine to standard thoracic epidural anesthesia significantly reduced mean pain scores at 24 hours (0.92 vs 2.44, p=0.0001) in patients undergoing esophagectomy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: