Controversies in the Management of ZollingerEllison Syndrome

Editorials1 December 1986Controversies in the Management of ZollingerEllison SyndromeAARON I. VINIK, M.B., B.Ch., M.D., NORMAN THOMPSON, M.D.AARON I. VINIK, M.B., B.Ch., M.D., NORMAN THOMPSON, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-6-956 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe Zollinger-Ellison syndrome is characterized by persistent basal gastric acid hypersecretion due to hypergastrinemia. Death from fulminant ulcer disease is now rarely seen, and death from progression of the tumor has become the major issue. Management of nearly all patients with this disease was previously by total gastrectomy, and no attempt was made to identify or remove the source of gastrin hypersecretion. Over the 3 decades since the syndrome's description, there has been much debate as to the optimal form of management (1-3). 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Author, Article, and Disclosure InformationAffiliations: The University of Michigan Ann Arbor, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeuroendocrine TumorsSecretory Neoplasms of the PancreasGastrinomas: A historical perspectivePancreatic endocrine tumorsZollinger-Ellison syndromeEndocrine Tumors of the PancreasPancreatic Endocrine TumorsENDOCRINE TUMORS OF THE GASTROINTESTINAL TRACTIslet Cell Tumors of the PancreasNeuroendocrine tumors of the pancreas and duodenumEndocrine Tumors of the PancreasPathologic aspects of gastrinomas in patients with Zollinger-Ellison syndrome with and without multiple endocrine neoplasia type ICurrent approach to the management of gastrinoma and insulinoma in adults with multiple endocrine neoplasia type IImaging Endocrine Tumours of the GutThe surgical treatment of the Zollinger-Ellison syndrome in sporadic and MEN-I patientsBenefit of resection of metastatic gastrinoma in multiple endocrine neoplasia type ISurgical pathology of gastrinoma. 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