Key result
Preoperative rTM rapidly resolves DIC, enabling safe open aortic aneurysm repair.
Why the study?
The management of abdominal aortic aneurysm complicated by symptomatic disseminated intravascular coagulation lacks established preoperative treatment strategies.
Does preoperative recombinant human soluble thrombomodulin improve coagulopathy in a patient with abdominal aortic aneurysm complicated by DIC?
Case Report (n=1)
No
Does preoperative recombinant human soluble thrombomodulin improve coagulopathy in a patient with abdominal aortic aneurysm complicated by DIC?
Preoperative administration of recombinant human soluble thrombomodulin may assist in the safe surgical treatment of aortic aneurysm complicated by DIC.
We herein present a case involving an 86-year-old man with abdominal aortic aneurysm complicated by symptomatic disseminated intravascular coagulation (DIC). The patient received preoperative treatment for DIC using recombinant human soluble thrombomodulin (rTM) followed by open surgical repair of the aneurysm. The patient's coagulopathy cleared quickly after the start of rTM, and the intraoperative and postoperative course went smoothly. The patient was followed without anticoagulant medication, and there was no recurrence of DIC during 14 months of follow-up. The preoperative administration of rTM can be a useful choice to assist safe treatment of aortic aneurysm complicated by aneurysm-related DIC.
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Yamamoto et al. (2023) conducted a case report in Disseminated intravascular coagulation associated with abdominal aortic aneurysm (n=1). Recombinant human soluble thrombomodulin (rTM) was evaluated on Resolution of coagulopathy and safe surgical repair. Preoperative administration of recombinant human soluble thrombomodulin rapidly resolved symptomatic disseminated intravascular coagulation, enabling safe open surgical repair of an aortic aneurysm.
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