Key result
Type 2 diabetes mellitus was associated with significantly higher serum levels of adiponectin (P≤0.04 in males, P≤0.02 in females) and leptin (P≤0.001) compared to nondiabetic controls.
Why the study?
Are serum adiponectin and leptin levels elevated in patients with type 2 diabetes mellitus and obesity compared to controls?
Case-Control (n=100)
Are serum adiponectin and leptin levels elevated in patients with type 2 diabetes mellitus and obesity compared to controls?
p-value: p=≤0.001
Serum adiponectin and leptin levels are significantly elevated in patients with type 2 diabetes and obesity, suggesting their potential utility as clinical markers.
Low adiponectin and high leptin may flag cardiometabolic risk in Indian T2DM; leaves open predictive utility or therapeutic targeting.
Introduction: Indian phenotype includes higher waist circumference despite lower body mass index, thereby making Indians more prone to diabetes and its complications. Aim: The present study aimed to analyze the serum levels of adiponectin and leptin in the participants with type 2 diabetes mellitus (T2DM) and obesity and their correlation with hypertension and dyslipidemia. Materials and Methods: In the study, 50 diabetics and 50 controls aged between 40 and 60 years were included in the study. Results: Adiponectin levels were significantly higher in diabetics than in nondiabetic participants irrespective of gender (P ≤ 0.04 in males, P ≤ 0.02 in females). Leptin levels were significantly higher in diabetics compared to nondiabetics (P ≤ 0.001) in both males and females. Conclusion: Adiponectin and leptin levels may be used as important clinical markers for T2DM and obesity.
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Ghadge et al. (2018) conducted a case-control in Type 2 diabetes mellitus and obesity (n=100). Type 2 diabetes mellitus vs. Nondiabetic controls was evaluated on Serum levels of adiponectin and leptin (p=≤0.001). Type 2 diabetes mellitus was associated with significantly higher serum levels of adiponectin (P≤0.04 in males, P≤0.02 in females) and leptin (P≤0.001) compared to nondiabetic controls.
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