Key result
RT3D-STI identifies coronary heart disease with ~92% diagnostic accuracy via global longitudinal strain.
Why the study?
The clinical value of real-time three-dimension speckle tracking imaging (RT3D-STI) in evaluating left ventricular systolic function in coronary artery disease patients was not established.
Does real-time three-dimension speckle tracking imaging (RT3D-STI) accurately evaluate left ventricular global systolic function and diagnose coronary artery disease?
Case-Control (n=89)
Does real-time three-dimension speckle tracking imaging (RT3D-STI) accurately evaluate left ventricular global systolic function and diagnose coronary artery disease?
RT3D-STI, particularly global longitudinal strain (GLS) and global area strain (GAS), can effectively detect early changes in left ventricular global systolic function in patients with coronary artery disease.
Objective To evaluate left ventricular systolic function by real-time three-dimension speckle tracking imaging (RT3D-STI) in coronary artery diseases (CHD) patients,to determine the clinical value of RT3D-STI in CHD.Methods 34 control subjects and 55 patients with CHD by coronary angiography were involved.Left ventricular global longitudinal strain (GLS),left ventricular global circumferential strain (GCS),left ventricular global radial strain (GRS),left ventricular global area strain (GAS) and left ventricular ejection fraction (LVEF),etc,was acquired by RT3D-STI,respectively.The parameters by RT3D-STI to diagnose CHD were analyzed.Results Compared with control group,GLS,GCS,GRS and GAS were significantly decreased in CHD group (P ＜ 0.05).The area under receiver operating characteristics (AUC) curve of GLS to diagnose CHD was 91.6％.The cutoff value,the sensitivity and Youden index of GLS were-12.5,90.3 ％ and 0.612,respectiuely.The cutoff value,the sensitivity and Youden index of GAS were-23.0,95.8％ and 0.539,respectiuely.GLS,GAS correlated well with LVEF in CHD group (r =-0.860,r =-0.926).Conclusions GLS is the most sensitivity and GAS is the most specificity in the all of strain parameters.RT3D-STI can early show the changes of left ventricular global systolic function in patients with CHD.
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Liu et al. (2013) conducted a case-control in Coronary artery diseases (n=89). Real-time three-dimension speckle tracking imaging (RT3D-STI) vs. Control subjects was evaluated on Left ventricular global strain parameters (GLS, GCS, GRS, GAS) (p=< 0.05). Real-time three-dimension speckle tracking imaging demonstrated significantly decreased global strain parameters in CHD patients (P<0.05), with global longitudinal strain achieving an AUC of 91.6%.
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