Key result
Three-dimensional speckle tracking echocardiography detected reduced global longitudinal, circumferential, and area strain in patients with 50-75% coronary stenosis despite preserved LVEF (P<0.05).
Why the study?
The study was conducted to use 3D-STE to evaluate left ventricular function in patients with triple vessel coronary artery disease without myocardial infarction.
Does three-dimensional speckle tracking echocardiography (3D-STE) detect subclinical left ventricular dysfunction in patients with triple vessel coronary artery disease without myocardial infarction?
Observational (n=90)
Does three-dimensional speckle tracking echocardiography (3D-STE) detect subclinical left ventricular dysfunction in patients with triple vessel coronary artery disease without myocardial infarction?
p-value: p=<0.05
3D-STE can detect subclinical left ventricular dysfunction through reduced strain parameters in patients with moderate triple vessel disease before LVEF declines.
3D-STE may detect subclinical LV impairment in TVD without MI; hypothesis-generating and requires prospective validation before clinical use.
Purpose Using three-dimensional speckle tracking echocardiography (3D-STE) to evaluate left ventricular (LV) function in patients with triple vessel coronary artery disease(TVD) without myocardial infarction. Methods Sixty patients with TVD without myocardial infarction were divided into two groups according to the results of coronary angiography. Group B (n=31)：50%≤the stenosis rates of all triple vessel coronary artery＜75%; Group C (n=29)：the stenosis rates of all triple vessel coronary artery≥75%. Thirty healthy subjects were recruited as the group A. We measured LV end-diastolic and end-systolic volume (LVEDV, LVESV) and LV ejection fraction (LVEF) using real-time three-dimensional echocardiography. The 3D-STE parameters of LV included global longitudinal strain (GLS), global area strain (GAS), global radial strain (GRS) and global circumferential strain (GCS). Results In group C, LVEDV and LVESV were significantly increased (all P ＜0.05), while LVEF, GLS, GRS, GCS and GAS were significantly decreased compared with groups A and B (all P ＜0.05). In groups A and B, there were no statistical differences in LVEDV, LVESV and LVEF. However, GLS, GCS and GAS were lower in group B than in group A (all P ＜0.05). Conclusion Our study shows that 3D-STE can evaluate the LV function in patients with triple vessel coronary artery disease without myocardial infarction through multiple strain parameters.
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Cui et al. (2021) conducted an observational in Triple vessel coronary artery disease without myocardial infarction (n=90). Triple vessel coronary artery disease vs. Healthy subjects was evaluated on Left ventricular function parameters including LVEDV, LVESV, LVEF, and 3D-STE strain parameters (p=<0.05). Three-dimensional speckle tracking echocardiography detected reduced global longitudinal, circumferential, and area strain in patients with 50-75% coronary stenosis despite preserved LVEF (P<0.05).
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