Key result
Dyslipidemia, especially mixed dyslipidemia, is linked to impaired LV global longitudinal peak strain.
Why the study?
To investigate the value of three-dimensional speckle-tracking echocardiography in evaluating early left ventricular systolic function across different types of dyslipidemia.
Does dyslipidemia impair left ventricular strain parameters measured by 3D-STE in patients with preserved LVEF?
Cross-Sectional (n=209)
No
Does dyslipidemia impair left ventricular strain parameters measured by 3D-STE in patients with preserved LVEF?
Effect estimate: AUC 0.905 (95% CI 0.842-0.953)
Absolute Event Rate: 17.15% vs 21.48%
p-value: p=<0.001
Three-dimensional speckle-tracking echocardiography can detect early subclinical left ventricular systolic dysfunction in patients with dyslipidemia and preserved LVEF, with LDL-C showing the strongest independent correlation with impaired longitudinal strain.
May signal subclinical LV impairment in dyslipidemia; leaves open whether 3D-STE strain guides management in preserved LVEF.
Purpose: To investigate the value of three-dimensional speckle-tracking echocardiography (3D-STE) in evaluating early left ventricular (LV) systolic function in patients with different types of dyslipidemia Methods: A total of 109 patients with dyslipidemia treated at our hospital were selected and divided into high total cholesterol (TC) group, high triglyceride (TG) group, low high-density lipoprotein cholesterol (HDL-C) group and mixed dyslipidemia group, according to the variety of dyslipidemia for further analysis.A total of 100 healthy volunteers approximately matched for age and gender were selected as the control group. The basic clinical data and conventional echocardiographic parameters were obtained, and the global longitudinal peak strain (GLPS), circumferential peak strain (GCPS) and radial peak strain (GRPS) of the left ventricle were obtained by 3D-STI technology for further analysis. Results: (1)The GLPS and GCPS of the high TC group, high TG group and low HDL-C group were lower than those of the control group, and the GLPS, GCPS and GRPS of the mixed dyslipidemia group were lower than those of the other groups. (2) The ROC curve analysis showed that the area under the curve (AUC) of GLPS for detecting dyslipidemia patients was the largest. (3) Linear regression analysis showed that GLPS was independently correlated with TC, LDL-C, TG, and HDL-C. The independent effect of LDL-C on GLPS (standardizedβ = -0.368) was stronger than that of TC (standardizedβ = -0.356), suggesting LDL-C has a greater impact on left ventricular longitudinal strain. (4)The Bland-Altman analysis showed that 3D-STE parameters had good intra-observer and inter-observer consistency. Conclusion: Dyslipidemia had adverse effects on left ventricular strain parameters, especially in patients with mixed dyslipidemia. 3D-STE effectively evaluated the global systolic function of LV in patients with different types of dyslipidemia, and LDL-C shows the strongest independent effect correlating with worse systolic function.
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Chen et al. (2026) conducted a cross-sectional in Dyslipidemia (n=209). Dyslipidemia vs. Healthy volunteers was evaluated on Global longitudinal peak strain (GLPS) (AUC 0.905, 95% CI 0.842-0.953, p=<0.001). Dyslipidemia, particularly mixed dyslipidemia, significantly reduced left ventricular global longitudinal peak strain compared to healthy controls (AUC 0.905), with LDL-C showing the strongest independent effect.
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