Key result
PCSK9 levels were significantly elevated in men with screen-detected hypertension compared to normotensive controls (median 365 vs 220 ng/ml), highlighting its potential as an early diagnostic biomarker.
Why the study?
The diagnostic usefulness of selected novel biomarkers for hypertension in men was evaluated to identify potential early screening markers.
Do novel biomarkers such as PCSK9 have diagnostic potential for identifying hypertension in men?
Cross-Sectional (n=88)
No
Do novel biomarkers such as PCSK9 have diagnostic potential for identifying hypertension in men?
PCSK9 and several microRNAs show potential as early diagnostic biomarkers for screening-detected hypertension in men.
Answers are grounded in this paper and cite their sources.
PCSK9 and select microRNAs may associate with hypertension in men; hypothesis-generating for early biomarkers, requiring prospective validation before any clinical adoption.
Introduction: The present study aimed to evaluate the diagnostic usefulness of selected novel parameters as biomarkers of hypertension: miR-145-5p, miR-1-3p, miR-423-5p, PCSK9, MyBPC3, NOX1, and CYBb, and NCF2, DNase 1, anti-MPO and anti-PR3 antibodies. Methods: We present the data of men with normal blood pressure, diagnosed hypertension, confirmed hypertension, and hypertension and coexisting coronary artery disease. Results: Elevated levels of miR-145-5p, miR-1-3p, and miR-423-5p and high levels of PCSK9, MyBPC3, and DNase 1 were observed in all groups of hypertensive men. We showed decreased levels of NOX1 and CYBb, and an elevated level of NCF2. Conclusions: PCSK9 shows the greatest potential as an early biomarker of screening-detected hypertension.
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Charkiewicz et al. (2022) conducted a cross-sectional in Hypertension (n=88). Hypertension vs. Normotensive controls was evaluated on Serum PCSK9 levels (ng/ml) (p=<0.05). PCSK9 levels were significantly elevated in men with screen-detected hypertension compared to normotensive controls (median 365 vs 220 ng/ml), highlighting its potential as an early diagnostic biomarker.
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