Key result
Homozygosity for interleukin-1A (IL-1A) allele 2 in the regulatory region (-889) was associated with a fivefold increased risk for multiple system atrophy.
Why the study?
Does homozygosity for IL-1A allele 2 increase the risk of multiple system atrophy?
Does homozygosity for IL-1A allele 2 increase the risk of multiple system atrophy?
Homozygosity for the IL-1A allele 2 is associated with a significantly increased risk of developing multiple system atrophy.
In a case-control study using a clinically well-defined group of 30 multiple system atrophy (MSA) patients and 110 control subjects, homozygosity for interleukin-1A (IL-1A) allele 2 (high secretor of proinflammatory cytokine) in the regulatory region (-889) of the IL-1A gene was associated with a fivefold increased risk for MSA.
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Combarros et al. (2003) studied this question. Homozygosity for interleukin-1A (IL-1A) allele 2 in the regulatory region (-889) was associated with a fivefold increased risk for multiple system atrophy.
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