Four naphthoquinoids from Kigelia pinnata rootbark were assessed in vitro against chloroquine-sensitive (T9-96) and -resistant (K1) Plasmodium falciparum strains and for cytotoxicity using KB cells. 2-(1-Hydroxyethyl)naphtho[2,3-b]furan-4,9-dione possessed good activity against both strains [IC(50) values 627 nM (K1), 718 nM (T9-96)]. Isopinnatal, kigelinol, and isokigelinol exhibited lower activity against both strains.
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Weiss et al. (2000) studied this question.
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