An Alternative Total Synthesis of (–)-Pyrenophorol

Aim: The aim of the present work is to report an alternative strategy to synthesis of (-)-Pyrenophorol.Methods: In this synthesis all intermediates and target compounds were fully characterized by different spectroscopic techniques such as 1 H NMR, 13 CNMR and EI-MS.Results and Discussion: The total synthesis of 16-membered C2-symmetric dilactone (-)-Pyrenophorol was prepared from (R, S)-di epoxide in 9 steps with good yields using Wittig olefination and Mitsunobu cyclization as key steps.Conclusion: A short and efficient stereoselective total synthesis of Pyrenophorol (1) has been achieved from the known di epoxide.The key steps includes Wittig olefination and dimerization by Mitsunobu cyclization.