Berbamine inhibits SARS-CoV-2 infection by compromising TRPMLs-mediated endolysosomal trafficking of ACE2

This is the authors' abstract. We don't add key points for this paper.

Middle East respiratory syndrome-related coronavirus (MERS-CoV) is the pathogen responsible for the outbreak of MERS, and we are currently being affected by coronavirus disease 2019 (COVID-19) due to infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The S protein of SARS-CoV-2 or MERS-CoV binds angiotensin-converting enzyme 2 (ACE2) or dipeptidyl peptidase-4 (DPP4), respectively, to facilitate viral particles entry into cells 1 . The COVID-19 pandemic has caused major socioeconomic disruptions globally.