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The WHO defined an Ameloblastic Carcinoma (AC) secondary type (dedifferentiated) intraosseous as a malignant neoplasm that "arises in a preexisting benign ameloblastoma.Dedifferentiated ameloblastoma is applied when morphologic features of typical ameloblastoma were noted.Microscopically, clusters or nests and islands of epithelium within a collagenous stroma are composed of a peripheral layer of polarized cells enclosing stellate to basaloid cells in the early transition of the de-differentiation stage.These cellular structures may show pleomorphism, frequent mitotic figures, indistinct cell membranes, focal necrosis, loss of cellular cohesion and infiltration along nerve bundles" [1].
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Guerrero et al. (2017) studied this question.
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