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March 1, 1995British Journal of Clinical PharmacologyOpen Access

Metabolic disposition of proguanil in extensive and poor metabolisers of S‐mephenytoin 4'‐hydroxylation recruited from an Indonesian population.

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Authors

RSRianto SetiabudyUniversity of IndonesiaMKM KusakaKCKazuhiro ChibaNational Defense Medical College Hospital

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Cite This Study

Setiabudy et al. (1995) studied this question.

synapsesocial.com/papers/6ab36686519217c1f23ebfe3https://doi.org/10.1111/j.1365-2125.1995.tb04452.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The activation of the biguanide antimalarial proguanil co‐segregates with the mephenytoin oxidation polymorphism‐a panel study.1991 · 165 citations
  2. 2Relation between chloroguanide bioactivation to cycloguanil and the genetically determined metabolism of mephenytoin in humans1992 · 28 citations
  3. 3The activity of proguanil and its metabolites, cycloguanil and<i>p</i>-chlorophenylbiguanide, against<i>Plasmodium falciparum in vitro</i>1984 · 64 citations
  4. 4In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme.1990 · 69 citations
  5. 5Rapid screening for polymorphisms in dextromethorphan and mephenytoin metabolism.1990 · 34 citations