Key result
PET-CT detected bone marrow involvement with a sensitivity of 53.3% and specificity of 100% compared to bone marrow aspiration and biopsy, missing almost half of the cases in T-cell lymphoma.
Why the study?
Can PET-CT replace bone marrow aspiration and biopsy (BMAB) in evaluating bone marrow involvement in patients with T-cell lymphoma?
Observational (n=60)
Can PET-CT replace bone marrow aspiration and biopsy (BMAB) in evaluating bone marrow involvement in patients with T-cell lymphoma?
Effect estimate: Sensitivity 53.3%, Specificity 100%
Absolute Event Rate: 13.3% vs 25%
PET-CT misses bone marrow involvement in almost half of T-cell lymphoma cases detected by BMAB and cannot substitute for biopsy in staging.
The role of 18F-fluoro-2-deoxy-D-glucose positron emission tomography combined with computerized tomography (PET-CT) in evaluation of bone marrow involvement (BMI) in patients with T-cell lymphoma (TCL) is poorly understood. We investigated whether PET-CT could replace bone marrow aspiration and biopsy (BMAB) in TCL. Sixty patients with newly diagnosed TCL who underwent both diagnostic PET-CT and BMAB were identified. BMI was tissue-confirmed in 15 (25%) cases, however only 8 of these 15 showed BMI on PET-CT (sensitivity of 53.3%, specificity of 100%). BMI by BMAB was associated with lower progression-free survival (PFS) (p = 0.038) and overall survival (OS) (p = 0.003) while PET-CT BMI was associated only with OS (p = 0.02). BMI detected by BMAB in the setting of a negative PET-CT had similar inferior prognosis as BMI identified on PET-CT. Thus, PET-CT in TCL misses BMI in almost half of the cases detected by BMAB and hence cannot substitute BMAB in evaluation of TCL.
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Sundaram et al. (2020) conducted an observational in T-cell lymphoma (n=60). PET-CT vs. Bone marrow aspiration and biopsy was evaluated on Bone marrow involvement (Sensitivity 53.3%, Specificity 100%). PET-CT detected bone marrow involvement with a sensitivity of 53.3% and specificity of 100% compared to bone marrow aspiration and biopsy, missing almost half of the cases in T-cell lymphoma.
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