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most consistently effective agent, especially when given as a single intravenous bolus, but haloperidol is also valuable.9Other drugs, including metoclopramide, clonazepam, and antiepileptics (carbamazepine,8 valproic acid,20 and pheny- toin), may be of value, particularly in neurogenic hiccups.More recent reports have described resolution of prolonged hiccups with amitriptyline,21 nifedipine,22 amantidine,23 and baclofen.24Classes of agents that have been beneficial in single cases or short reports include tricyclic antidepressants, anticholinergics, benzodiazepines, stimulants of the central nervous system, H2 receptor antagonists, and dopamine agonists.When faced with a patient with intractable hiccups it is necessary to exclude or treat any underlying disease.Then, if simple physical measures fail to abort the attack and the hiccups last for longer than 24 hours, treatment with chlorpromazine, metoclopramide, antiepileptics, or baclofen should be considered.