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We have synthesized (Pro‐Pro‐βAla)n as a model for collagen. The synthetic polytripeptide, mol wt 6500, exhibits a large negative optical rotation with a very strong negative Cotton effect centered at 216 nm. The optical rotatory dispersion of (Pro‐Pro‐βAla)n followed a single‐term Drude equation and the λc was 195 nm. The rotation decreased markedly on heating with the midpoint of the broad transition at 55°C. Preliminary studies also showed loss of structure in guadinine HCl. The circular dichroism spectrum of the polymer exhibited a deep trough at 190 nm. The marked similarities of solution properties of (Pro‐Pro‐βAla)n to (Pro‐Pro‐Gly)n suggest that β‐alanine can replace glycine in generating collagen‐like helix in solution.
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BHATNAGAR et al. (1975) studied this question.
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