Key result
Early monitoring and regimen adjustments effectively manage trastuzumab cardiotoxicity to restore cardiac function.
Why the study?
Concerns about trastuzumab cardiac safety and toxicity have persisted since its introduction in HER2-positive breast cancer treatment, necessitating understanding of detection and management strategies.
How can trastuzumab-induced cardiac toxicity be detected, prevented, and managed in patients with HER2-positive breast cancer?
How can trastuzumab-induced cardiac toxicity be detected, prevented, and managed in patients with HER2-positive breast cancer?
Understanding the characteristics and proper management of trastuzumab-induced cardiac toxicity is essential to safely provide optimal breast cancer treatment.
Trastuzumab cardiotoxicity monitoring remains essential in HER2+ breast cancer; level 5 evidence leaves open optimal prevention strategies.
Trastuzumab has gained a central role in the treatment of HER2-positive breast cancer, revolutionizing care in this setting. However, since the beginning of its use there have been concerns about its cardiac safety. Trastuzumab can give rise to cardiac toxicity, in some cases leading to discontinuation of treatment. Growing evidence shows that trastuzumab toxicity can be detected early or averted by means of new chemotherapy regimens using different anthracycline formulations or avoiding anthracyclines altogether. Moreover, patients in whom cardiac toxicity develops can be treated effectively and full cardiac function can be restored thanks to progress in drug management. Knowing the characteristics and proper management of trastuzumab toxicity is of paramount importance to grant patients in this setting the best available treatment.
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Bregni et al. (2015) conducted a review in HER2-positive breast cancer. Trastuzumab was evaluated. Trastuzumab-induced cardiac toxicity in HER2-positive breast cancer can be detected early, averted with alternative regimens, and effectively managed to restore full cardiac function.
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