Key result
Each 1% increase in global longitudinal strain was associated with a 1.14-fold increased likelihood of left ventricular reverse remodeling (OR 1.14; 95% CI 1.01-1.31; p < 0.05).
Why the study?
The utility of global longitudinal strain as a reliable predictor of left ventricular reverse remodeling after mitral valve replacement surgery in severe primary mitral regurgitation patients was unclear.
Does global longitudinal strain predict left ventricular reverse remodeling in patients undergoing valve replacement surgery for severe primary mitral regurgitation?
Observational (n=103)
Does global longitudinal strain predict left ventricular reverse remodeling in patients undergoing valve replacement surgery for severe primary mitral regurgitation?
Odds Ratio: 1.14 (95% CI 1.01–1.31)
p-value: p=< 0.05
Preoperative global longitudinal strain is an independent predictor of left ventricular reverse remodeling after mitral valve replacement surgery in patients with severe primary mitral regurgitation.
GLS may aid LVRR risk stratification after severe primary MR surgery; leaves open whether it should guide decisions or improve outcomes.
OBJECTIVES: This study aimed to identify the utility of global longitudinal strain (GLS) as a reliable parameter that can accurately forecast left ventricle reverse remodeling (LVRR) in patients undergoing valve replacement surgery for severe chronic primary mitral regurgitation (MR), thereby aiding in assessing mortality and morbidity risk. METHODS: This retrospective observational study involved severe primary MR patients who underwent valve replacement surgery between 2018 and 2023. Pre- and postsurgery echocardiography data were collected, with GLS measurements utilized to assess left ventricular function. Various echocardiography parameters, including MR severity and LV dimensions, were analyzed. Bivariate and multivariate analyses were performed to explore relationships between GLS and LVRR. RESULTS: This study enrolled 103 patients (54.4% male; mean age 45.4 ± 13.6 years). Statistical analyses revealed GLS to be an independent predictor of LVRR, with a threshold of -16.25% showing 89% sensitivity and 50% specificity. Each 1% increase in GLS corresponded to a 1.14-fold (odds ratio [OR]: 1.14; 95% confidence interval [CI]: 1.01-1.31; p < 0.05) increased likelihood of LVRR. CONCLUSION: These findings highlight GLS's potential as a prognostic marker for postsurgical outcomes in severe MR patients.
No takes yet. Share an insight, caveat, or question.
Natalino et al. (2024) conducted an observational in Severe chronic primary mitral regurgitation (n=103). Global longitudinal strain (GLS) was evaluated on Left ventricle reverse remodeling (LVRR) (OR 1.14, 95% CI 1.01-1.31, p=< 0.05). Each 1% increase in global longitudinal strain was associated with a 1.14-fold increased likelihood of left ventricular reverse remodeling (OR 1.14; 95% CI 1.01-1.31; p < 0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: