What question did this study set out to answer?

This study examines the effectiveness of global longitudinal strain (GLS) in predicting long-term left ventricular dysfunction after mitral valve repair.

July 29, 2012European Heart Journal - Cardiovascular ImagingOpen Access

Global longitudinal strain predicts left ventricular dysfunction after mitral valve repair

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Why the study?

Does preoperative global longitudinal strain predict long-term left ventricular dysfunction in patients undergoing mitral valve repair for organic mitral regurgitation?

Population

233 patients with moderate-severe organic mitral regurgitation who underwent successful mitral valve repair…

Design

Cohort

Follow-up

34 ± 20 months

Authors

TWTomasz G. WitkowskiWroclaw Medical University JTJames D. ThomasNorthwestern Memorial Hospital PDPhilippe DebonnaireStructural Heart Disease

Discussion

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Implication

Preoperative GLS >-19.9% may flag high-risk mitral repair patients; leaves open whether GLS integration improves outcomes.

Key Points

This study examines the effectiveness of global longitudinal strain (GLS) in predicting long-term left ventricular dysfunction after mitral valve repair.
233 patients with moderate-severe organic mitral regurgitation who underwent successful mitral valve repair were studied.
Echocardiography assessments were made at baseline and long-term follow-up (average 34 months).
Predictive analyses were performed using univariate and multivariate logistic regression.
29 patients (12%) experienced left ventricular dysfunction (LVEF <50%) at follow-up.
GLS cut-off value of -19.9% predicted long-term LV dysfunction with 90% sensitivity and 79% specificity.
GLS was identified as an independent predictor with an odds ratio of 23.16 (95% CI: 6.53-82.10, P < 0.001).

Structured PICO

Does preoperative global longitudinal strain predict long-term left ventricular dysfunction in patients undergoing mitral valve repair for organic mitral regurgitation?

Population

233 patients with moderate-severe organic mitral regurgitation who underwent successful mitral valve repair, mean age 61 ± 12 years, 61% men.

Intervention

Preoperative left ventricular global longitudinal strain (GLS) assessment using speckle-tracking echocardiography

Outcome

Long-term left ventricular dysfunction (defined as LV ejection fraction <50%) at 34 ± 20 months follow-upsurrogate

Preoperative global longitudinal strain >-19.9% strongly predicts long-term left ventricular dysfunction after mitral valve repair, suggesting its utility in detecting subclinical dysfunction.

Cite This Study

Witkowski et al. (2012) studied this question.

synapsesocial.com/papers/6a758be93e2789f4c25ffc24 https://doi.org/10.1093/ehjci/jes155

Topics

Mitral valve intervention Echocardiography

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Global longitudinal strain predicts left ventricular dysfunction after mitral valve repair

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Global longitudinal strain predicts left ventricular dysfunction after mitral valve repair

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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