P1485Prognostic value of left ventricular global longitudinal strain in patients with significant secondary mitral regurgitation

Background: In patients with secondary mitral regurgitation (MR), left ventricular (LV) systolic function may be overestimated when using LV ejection fraction (EF). In contrast, LV global longitudinal strain (GLS) has been shown to better estimate of the true LV systolic function. However, the prognostic implications of LV GLS in patients with significant secondary MR has not been elucidated. Purpose: The aim of this study was to investigate the prognostic value of LV GLS in a large cohort of patients with significant secondary MR. Methods: A total of 444 patients (67±11 years old, 68% male) with moderate to severe secondary MR and echocardiographic images feasible for LV GLS analysis were evaluated. Patients were divided in 2 groups according to the median of LV GLS: patients with LV GLS ≤ -7.3% (better LV systolic function) and patients with LV GLS > -7.3% (worse LV systolic function). In addition, patients were divided according to the LVEF cut-off value proposed by current guidelines (≤30% vs. >30%). The primary endpoint was all-cause mortality.