Key result
The MTHFR A1298C polymorphism and elevated homocysteine levels were identified as significant risk factors for placental vasculopathies, whereas the C677T polymorphism showed no association.
Why the study?
Are MTHFR C677T and A1298C polymorphisms and elevated homocysteine levels associated with an increased risk of placental vasculopathies?
Case-Control (n=203)
Are MTHFR C677T and A1298C polymorphisms and elevated homocysteine levels associated with an increased risk of placental vasculopathies?
The MTHFR A1298C polymorphism, but not C677T, is associated with elevated homocysteine levels and an increased risk of placental vasculopathies.
May inform targeted risk assessment in pregnancy; hypothesis-generating and requires prospective validation before clinical adoption.
Our aim in this study was to investigate the association between elevated homocysteine levels and the two MTHFR polymorphisms, C677T and A1298C, with several pregnancy complications such as recurrent pregnancy loss, preeclampsia, placental abruption and intrauterine growth retardation. In 203 women with different placental vasculopathies, we determined the MTHFR C677T and the A1298C prevalence and their relative association to elevated homocysteine levels. The mean plasma homocysteine level was significantly higher in the pathologic groups when compared with the control group. We identified the carriage of the MTHFR A1298C polymorphism as a significant risk factor for vascular-related pregnancy complications. Women with MTHFR A1298C polymorphism or elevated homocysteine levels have an increased risk of placental vasculopathies. The MTHFR A1298C mutation also had a positive impact on elevated homocysteine levels. The lack of association between the MTHFR C677T polymorphism and pregnancy morbidities needs further studies.
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Klai et al. (2011) conducted a case-control in Placental vasculopathies (n=203). MTHFR A1298C polymorphism and elevated homocysteine vs. Control group was evaluated on Placental vasculopathies. The MTHFR A1298C polymorphism and elevated homocysteine levels were identified as significant risk factors for placental vasculopathies, whereas the C677T polymorphism showed no association.
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