Key result
Combined NT-proBNP and uric acid predicts 3-year mortality after STEMI revascularization with an AUC of ~0.80.
Why the study?
The prognostic value of NT-proBNP and uric acid in acute STEMI patients after complete revascularization was not well established.
Do serum NT-proBNP and uric acid levels predict 3-year overall survival in acute STEMI patients after complete revascularization?
Observational (n=185)
No
Do serum NT-proBNP and uric acid levels predict 3-year overall survival in acute STEMI patients after complete revascularization?
Elevated serum NT-proBNP and uric acid levels are strong predictors of poor 3-year overall survival in acute STEMI patients following complete revascularization.
May support risk stratification with NT-proBNP and UA post-CR STEMI; leaves open incremental value over existing models.
OBJECTIVES: To explore the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and uric acid (UA) in acute ST-segment elevation myocardial infarction (STEMI) patients after complete revascularization (CR). METHODS: The clinical and physical data from 125 acute STEMI patients (research group) who underwent CR between December 2017 and December 2020 and 60 healthy individuals (control group) who concurrently underwent physical examinations in the Affiliated Hospital of Guizhou Medical University were retrospectively analyzed in this study. Serum samples were collected from both groups to determine the levels of NT-proBNP and UA. The 3-year follow-up data of acute STEMI patients were collected, which were used to group the patients into a good and a poor prognosis group based on their prognoses to comparatively analyze NT-proBNP and UA levels. Receiver operating characteristic (ROC) curves were drawn to analyze the prognostic value of NT-proBNP and UA in STEMI patients following CR, and survival curves were plotted to observe their influences on patients' 3-year overall survival (OS). Meanwhile, a univariate analysis was conducted to identify factors associated with the 3-year OS of acute STEMI patients after CR. RESULTS: The data showed significantly higher expression levels of serum NT-proBNP and UA in acute STEMI patients than in the controls. Besides, the good prognosis group exhibited markedly lower serum NT-proBNP and UA levels than the poor prognosis group. The areas under the curve (AUCs) of NT-proBNP and UA in predicting the prognosis of acute STEMI patients after CR were all above 0.700, and the AUC of their combined detection reached over 0.800. In addition, high serum NT-proBNP and UA levels were strongly associated with lower 3-year OS rates. As indicated by the univariate analysis, a history of smoking and alcoholism as well as high NT-proBNP and UA levels were closely associated with 3-year OS in acute STEMI patients after CR. CONCLUSIONS: NT-proBNP and UA have promising prognostic value in acute STEMI after CR.
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Kang Li (2024) conducted an observational in Acute ST-segment elevation myocardial infarction (STEMI) (n=185). Combined detection of NT-proBNP and Uric Acid vs. Individual detection or low levels was evaluated on Prediction of 3-year prognosis (good vs poor based on MACCE-related death) (AUC 0.804, 95% CI 0.705-0.903). The combined detection of serum NT-proBNP and uric acid demonstrated high prognostic value for 3-year overall survival in acute STEMI patients after complete revascularization, with an AUC of 0.804.
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