Key result
Serum BLACAT1 expression demonstrated high diagnostic performance across 12 cancer types with AUCs ranging from 0.833 to 0.967, and high expression was associated with poor overall survival in endometrial cancer.
Why the study?
Does BLACAT1 expression serve as a diagnostic and prognostic biomarker in common types of human cancer?
Observational (n=1,080)
Does BLACAT1 expression serve as a diagnostic and prognostic biomarker in common types of human cancer?
Effect estimate: AUC 0.833 to 0.967
p-value: p=<0.01
BLACAT1 may serve as a non-specific diagnostic biomarker for multiple cancers and a prognostic biomarker for endometrial cancer.
Serum BLACAT1 may support non-specific cancer diagnosis but should not yet change practice; leaves open its endometrial cancer prognostic role pending validation.
A growing number of evidence has indicated that long non-coding RNAs (lncRNA) may have many functions in the development and progression of cancer, and cloud serve as good diagnostic and prognostic biomarkers in cancers. However, these studies often revealed the changes of lncRNAs within a specific cancer type. Here, we focused on BLACAT1 and provided a comprehensive pan-cancer analysis to evaluate the diagnostic and prognostic values of BLACAT1. The expression data of BLACAT1 were came from the quantitative real-time polymerase chain reaction (qRT-PCR) and The Cancer Genome Atlas (TCGA) database, respectively. Our results showed that the change of serum BLACAT1 expression was similar to those in matched tissues. The expression level of BLACAT1 both in serum and tissues in multiple cancer types were significantly upregulated compared to those of matched non-cancer participants. The serum BLACAT1 had a high diagnostic performance among these 12 types of cancer. The relative AUC of serum BLACAT1 in cancer patients ranged from 0.833 to 0.967 compared to that in healthy subjects. Surprisingly, Kaplan-Meier survival analysis revealed that the high expression level of BLACAT1 was significantly associated with poor overall survival only in uterine corpus endometrial carcinoma (p = 0.002, log-rank test). These findings demonstrated that BLACAT1 could act as a non-specific diagnostic biomarker for cancers and a potential biomarker for prognosis prediction of endometrial cancer.
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Chen et al. (2017) conducted an observational in Cancer (n=1,080). Serum BLACAT1 expression vs. Healthy subjects and low BLACAT1 expression was evaluated on Diagnostic performance (Area Under the Curve) for distinguishing cancer from healthy subjects (AUC 0.833 to 0.967, p=<0.01). Serum BLACAT1 expression demonstrated high diagnostic performance across 12 cancer types with AUCs ranging from 0.833 to 0.967, and high expression was associated with poor overall survival in endometrial cancer.
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