Key result
In patients with cardiogenic shock, survivors had significantly greater mean lactate clearance at 24 hours compared with non-survivors (54.63% vs 26.34%; P<0.01).
Why the study?
Is lactate clearance associated with in-hospital mortality in patients with cardiogenic shock?
Population
90 patients with cardiogenic shock and elevated baseline lactate (≥2.0 mmol/L).
Design
Cohort
Follow-up
in-hospital
Authors
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Greater 24-h lactate clearance was associated with survival in cardiogenic shock; supports its role as a prognostic marker but leaves open prospective validation before guiding therapy.
Observational (n=90)
Is lactate clearance associated with in-hospital mortality in patients with cardiogenic shock?
Absolute Event Rate: 54.63% vs 26.34%
p-value: p=< 0.01
Lactate clearance at 12 and 24 hours is significantly greater in survivors of cardiogenic shock, supporting its use as a prognostic marker and potential therapeutic target.
Nandikonda et al. (2023) conducted an observational in Cardiogenic shock (n=90). In-hospital survival vs. In-hospital non-survival was evaluated on Mean lactate clearance at 24 hours (p=< 0.01). In patients with cardiogenic shock, survivors had significantly greater mean lactate clearance at 24 hours compared with non-survivors (54.63% vs 26.34%; P<0.01).
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