Key result
Anti-gp135 antibody titers in synovial fluid and serum directly predict the histologic severity of carpal arthritis in goats chronically infected with caprine arthritis-encephalitis virus.
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Hypothesis-generating in this caprine model; leaves open whether anti-gp135 titers inform diagnostics or interventions in lentiviral arthritis.
Antibody titers to caprine arthritis-encephalitis virus surface glycoprotein gp135 and core protein p28 in synovial fluid and serum from 35 goats infected for 3 years were compared with the histologic severity of arthritis in these animals. Anti-gp135 antibody titers in synovial fluid and serum directly reflect the severity of carpal arthritis in chronically infected goats.
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Knowles et al. (1990) studied this question. Anti-gp135 antibody titers in synovial fluid and serum directly predict the histologic severity of carpal arthritis in goats chronically infected with caprine arthritis-encephalitis virus.
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