Key result
A high Framingham risk score was associated with an increased risk of incident chronic kidney disease (HR 2.674; 95% CI 2.197-3.255) in the general population.
Why the study?
Does the Framingham risk score predict incident chronic kidney disease in the general population with normal renal function?
Cohort
Does the Framingham risk score predict incident chronic kidney disease in the general population with normal renal function?
Hazard Ratio: 2.674 (95% CI 2.197–3.255)
p-value: p=< 0.001
The Framingham risk score can predict incident chronic kidney disease and enhance risk stratification when combined with traditional renal parameters.
Framingham risk score stratifies incident CKD risk; supports broader prediction models but remains hypothesis-generating without prospective validation.
BACKGROUND: Cardiovascular disease and chronic kidney disease share several common risk factors. The Framingham risk score is hypothesized to predict chronic kidney disease development. We determined if the Framingham risk scoring system can correctly predict incident chronic kidney disease in the general population. METHODS: ). RESULTS: < 0.001). Multivariable analysis after adjustment for confounding factors showed the hazard ratios for the high- and intermediate risk groups were 2.674 (95% confidence interval [CI], 2.197-3.255) and 1.734 (95% CI, 1.447-2.078), respectively. This association was consistently observed irrespective of proteinuria, age, sex, obesity, or hypertension. The predictive power of this scoring system was lower than that of renal parameters, such as eGFR and proteinuria, but increased when both were included in the prediction model. CONCLUSION: The Framingham risk score predicted incident chronic kidney disease and enhanced risk stratification in conjunction with traditional renal parameters in the general population with normal renal function.
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Lee et al. (2019) conducted a cohort in Chronic kidney disease. High Framingham risk score vs. Lower risk groups was evaluated on Incident chronic kidney disease (HR 2.674, 95% CI 2.197-3.255, p=< 0.001). A high Framingham risk score was associated with an increased risk of incident chronic kidney disease (HR 2.674; 95% CI 2.197-3.255) in the general population.
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